AtaGenix Laboratories

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Peptide synthesis

AtaGenix provides custom peptide synthesis services using solid-phase peptide synthesis (SPPS) for sequences up to 101 amino acids, with purity options from crude to >99%. Specialized modification capabilities include phosphorylation, methylation, acetylation, and crotonylation — directly supporting our antibody development platform for PTM-specific immunogen preparation and epitope mapping.

101 aa

Max Length

>99%

Highest Purity

~2 wks

Standard Delivery

mg–kg

Production Scale

Every peptide is delivered with HPLC purity analysis and mass spectrometry (MS) verification. Carrier protein conjugation (KLH, BSA, OVA) is available for immunization-ready antigen preparation — seamlessly connecting to our polyclonal and monoclonal antibody production pipelines.

Service Categories

Service What's Included Timeline
Standard Peptide (≤30 aa) Custom peptide + HPLC report + MS verification ~2 weeks
Long Peptide (31–101 aa) Custom peptide + HPLC + MS; may require optimization Consult
Modified Peptide Phospho / methyl / acetyl / crotonyl + HPLC + MS Consult
Carrier Conjugation Peptide + KLH / BSA / OVA conjugation for immunization Add ~1 week
Gram-Scale Production mg to kg scale; purity up to >99% Consult

Modification Expertise

Phosphorylation, methylation, acetylation, crotonylation, and custom chemical modifications. Essential for PTM antibody immunogen preparation — we synthesize both modified and unmodified peptides for two-round affinity purification.

Integrated with Antibody Services

Peptide synthesis + carrier conjugation + immunization + antibody production in one project. No need to coordinate between peptide vendor and antibody CRO — we handle the entire chain from epitope design to validated antibody.

Full QC Documentation

Every peptide ships with HPLC purity analysis and mass spectrometry identity confirmation. Multiple purity grades available: crude, desalted, >75%, >85%, >95%, and >99% to match your application requirements.

Contact Us

AtaGenix's peptide synthesis platform uses solid-phase peptide synthesis (SPPS) to produce custom peptides up to 101 amino acids in length, from milligram to kilogram scale. Purity options range from crude to >99% (HPLC-purified). Specialized modifications include phosphorylation, methylation, acetylation, and crotonylation for PTM research. Carrier protein conjugation (KLH, BSA, OVA) is available for direct use as immunogens in our polyclonal and monoclonal antibody pipelines. Standard delivery: ~2 weeks for peptides ≤30 aa. All peptides include HPLC and MS QC reports.

Peptide Synthesis Workflow

A standardized pipeline from sequence design to QC-verified peptide delivery. Carrier conjugation and downstream antibody production available as integrated services.

01

Sequence Design

Epitope selection
Modification site design
Solubility assessment

02

SPPS Synthesis

Solid-phase synthesis
Modification incorporation
Cleavage & deprotection

03

Purification & QC

HPLC purification
MS identity confirmation
Purity grade selection

04

Conjugation & Delivery

KLH / BSA / OVA (optional)
Lyophilized peptide
HPLC + MS reports

Service Scope

 Custom peptide synthesis up to 101 amino acids  Purity: crude, desalted, >75% to >99%
 Phosphorylation, methylation, acetylation, crotonylation  Custom chemical modifications
 Carrier conjugation: KLH, BSA, OVA  Milligram to kilogram scale
 HPLC purity analysis included  MS identity verification included
 Lyophilized delivery format  Integrated with antibody production pipeline

Available Modifications

Modification Application Downstream Use
Phosphorylation pSer, pThr, pTyr site-specific phosphorylation Phospho-specific antibody immunogen
Methylation Mono/di/tri-methylation on Lys or Arg Histone methylation antibody immunogen
Acetylation Lys acetylation at specific residues Acetylation-specific antibody immunogen
Crotonylation Lys crotonylation for epigenetic research Crotonylation antibody immunogen

Need antibodies from your peptide? Connect directly to our Polyclonal Antibody or Hybridoma pipeline. For PTM-specific antibodies with modified + unmodified two-round purification, see Anti-PTM Service. For epitope mapping via phage display, explore our Naïve Library Panning with peptide libraries (LiPep-7, LiPep-12).

Frequently Asked Questions

What is the maximum peptide length you can synthesize?

Up to 101 amino acids using solid-phase peptide synthesis (SPPS). Standard peptides (≤30 aa) are delivered in approximately 2 weeks. Longer peptides (31–101 aa) may require additional optimization time and are quoted individually based on sequence complexity, hydrophobicity, and required purity.

What purity levels are available?

We offer crude, desalted, and HPLC-purified peptides at >75%, >85%, >95%, and >99% purity. For immunization, ≥85% is typically sufficient. For quantitative assays (ELISA standards, SPR), ≥95% is recommended. For structural studies (NMR, X-ray), >99% is available.

Can you synthesize modified peptides for PTM antibody production?

Yes — this is one of our core strengths. We synthesize both the modified peptide (phospho/methyl/acetyl/crotonyl) for immunization and the unmodified counterpart for negative selection during antibody purification. This two-peptide approach is essential for generating PTM-specific antibodies that do not cross-react with the unmodified form. The peptides integrate directly into our Anti-PTM antibody production pipeline.

What carrier proteins are available for conjugation?

KLH (Keyhole Limpet Hemocyanin) is the default for immunization antigens due to its high immunogenicity. BSA (Bovine Serum Albumin) is used for ELISA coating conjugates. OVA (Ovalbumin) serves as an alternative carrier when BSA cross-reactivity is a concern. Custom carrier proteins are available upon request. All conjugations use optimized crosslinking chemistry with QC verification.

Synthesis feasibility depends on sequence complexity, hydrophobicity, and required modifications. Difficult sequences (multiple Cys, poly-Arg/Lys, highly hydrophobic stretches) may require optimization. Quote-based pricing.

 

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