AtaGenix Laboratories

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Naïve Library Panning

AtaGenix’s naïve library technology enables rapid antibody discovery with high diversity (up to 10¹⁰ variants) while eliminating the need for animal immunization. Compared to hybridoma technology, our phage display approach reduces turnaround time to 3-4 months and removes the need for further humanization, ensuring efficient and cost-effective therapeutic antibody development.

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Available Naïve Libraries at AtaGenix

 
Library Format Species Size(Capacity)
LiAb-SFCOVID-19™ scFv Human – COVID-19 recovered donors 1.35 × 10¹⁰
LiAb-SFMAX™ scFv Human – 5 ethnic groups, 368 donors 7.38 × 10¹⁰
LiAb-SFAutoimmune™ scFv Human – with autoimmune disease 4.78 × 10⁹
LiAb-VHHMAX™ VHH Camel, llama, alpaca , 76 donors 2.71 × 10¹⁰
LiAb-SFDab™ scFv Dog – 6 breeds,26 donors 1.52 × 10¹⁰
LiAb-SFCab™ scFv Cat – 10 breeds,78 donors 1.67 × 10¹⁰
LiAb-SFRab™ scFv Rabbit– 5 breeds,64 donors 2.95 × 10¹⁰
LiPep-12 Peptide 12-mer / 1.00 × 10⁹
LiPep-7 Peptide 7-mer / 1.00 × 10⁹

Biopanning Protocol in Phage Display

 
Biopanning Process

Example of the **panning (biopanning) protocol** in **Phage Display**:

  • Step 1: Incubation with phage library
  • Step 2: Wash away non-binders
  • Step 3: Elution of binders
  • Step 4: 3 to 5 rounds of panning/biopanning process
  • Step 5: ELISA to determine specificity of binding

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