Precision Solutions

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  IdeS & EndoS: Structural Mechanism and Clinical Applications in Autoimmune Disease and Gene Therapy

  A Nature Communications study resolved the crystal structures of IdeS–IgG1 Fc and EndoS–IgG1 Fc complexes, revealing the molecular basis of substrate-specific recognition. IdeS cleaves the IgG hinge region; EndoS hydrolyzes the Fc N-glycan. Clinical applications include Guillain-Barré syndrome (37% independent walking at week 1), AAV gene therapy antibody clearance (Nature Medicine 2020), and anti-GBM renal disease (GOOD-IDES Phase II). AtaGenix offers recombinant IdeS protease (ATE00010, >95% purity, 40 U/μL).