IdeS Protease

ATE00010

IdeS Protease

Immunoglobulin G-degrading Enzyme | Recombinant, E. coli-expressed

Product Description

An efficient and reliable enzymatic tool for research on antibody-based drugs and Fc fusion proteins. IdeS Protease is a cysteine endopeptidase secreted by Streptococcus pyogenes, known for its exceptional substrate specificity. It cleaves IgG at a specific site within the hinge region, hydrolyzing it into intact F(ab')₂ fragments and Fc fragments.

Product Advantages

High Purity Soluble, high-yield expression with low host protein residues; purity >95% by SDS-PAGE.

Superior Cleavage Performance Suitable for structural characterization of therapeutic antibodies, Fc fusion proteins, and ADCs.

High Enzyme Activity Activity >40 U/μL, specifically cleaving IgG antibodies to obtain targeted fragments.

Animal-Free Recombinant expression with no animal-derived raw materials; no risk of exogenous viral contamination.

Applications

Therapeutic Antibody Characterization
Fc Fusion Protein Analysis
ADC Characterization
Antibody Drug Development

Product Specifications

Attribute	Details
Product Name	IdeS Protease
Alias	Immunoglobulin G-degrading Enzyme
Catalog Number	ATE00010
Host	E. coli
Tag	N-terminal His Tag
Molecular Weight	37.56 kDa
Form	Liquid
Storage Buffer	PBS (pH 7.4), 50% glycerol
Purity	>95% (by SDS-PAGE)
Activity	40 U/μL
Specific Activity	40,000 U/mg
Reaction Conditions	37°C for 30 minutes
Storage	-20°C; shelf life 12 months
Shipping	Blue ice