普健生物(武汉)科技有限公司(AtaGenix)

Anti TMPRSS2 polyclonal antibody

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ATP226
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产品名(Product Name)icon
Anti TMPRSS2 polyclonal antibody
货号(Catalog No.)icon
ATP226
种类(Category)icon
Primary antibody
宿主(Host)icon
Rabbit
反应种属(Species specificity)icon
Human,other species was not test
应用实验(Tested applications)icon
WB:1:2000~1:8000,ICC:1:50~200,IHC:1:50~100
克隆性(Clonality)icon
Polyclonal
偶连物(Conjugation)icon
Unconjugated
免疫原(Immunogen)icon
Recombinant protein of human TMPRSS2(Ser284-Gly492)
别名icon
Transmembrane protease serine 2,Serine protease 10,Transmembrane protease serine 2 non-catalytic chain,Transmembrane protease serine 2 catalytic chain,PRSS10
Uniprot IDicon
O15393
Noteicon
For research use only .
状态(Form)icon
Liquid
储存溶液(Buffer)icon
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
存放条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4°C for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.
浓度(Concentration)icon
0.5mg/ml
亚型(Isotype)icon
IgG
分子量(MW)icon
54kDa
纯化方式(Purity)icon
Antigen affinity purification
WB,ICC,IHC
    PMID: 23468491, 30626688;PMID: 32142651, 30626688 ;PMID: 32142651;PMID: 25734995, 20382709, 26018085
    TMPRSS2, also named as PRSS10, is a type II transmembrane serine protease which is highly expressed by the epithelium of the human prostate gland. TMPRSS2 may contribute to prostate tumour metastasis via the activation of PAR-2. TMPRSS2 is a Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. TMPRSS2 as a host cell factor that is critical for spread of several clinically relevant viruses, including influenza A viruses and coronaviruses.SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. The initial spike protein priming by TMPRSS2 is essential for entry and viral spread of SARS-CoV-2 through interaction with the ACE2 receptor.Camostat mesylate, an inhibitor of TMPRSS2, can block SARS-CoV-2 infection of lung cells.The MW of TMPRSS2 is about 65-70 kDa. It can be cleaved in to some chains with MW 54 kDa, 31 kDa and 26 kDa

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