英文全称
Recombinant Human CYP11B1 protein
纯度(Purity)
>90% as determined by SDS-PAGE
内毒素(Endotoxin level)
Please contact with the lab for this information.
蛋白构建(Construction)
A DNA sequence encoding the human CYP11B1 (Gly134-Asn503) was fused with GST tag
Accession #
P15538
表达宿主(Host)
E.coli
种属(Species)
Homo sapiens (Human)
预测分子量(Predicted Molecular Mass)
68.99 kDa
制剂(Formulation)
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4%Trehalose, 1% Mannitol.
运输方式(Shipping)
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性&储存(Stability &Storage)
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
复溶(Reconstitution)
Reconstitute in sterile water for a stock solution.
背景介绍
A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids . Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) .
分子别名(Alternative Names)
Cytochrome P450 11B1, mitochondrial,CYPXIB1,Cytochrome P-450c11,Cytochrome P450C11,Steroid 11-beta-hydroxylase, CYP11B1.