普健生物(武汉)科技有限公司(AtaGenix)

Anti IL6RA polyclonal antibody

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ATP112
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产品名(Product Name)icon
Anti IL6RA polyclonal antibody
货号(Catalog No.)icon
ATP112
种类(Category)icon
Primary antibody
宿主(Host)icon
Rabbit
反应种属(Species specificity)icon
Human,other species was not test
应用实验(Tested applications)icon
WB:1:2000~1:8000,ICC:1:50~200,IHC:1:50~100
克隆性(Clonality)icon
Polyclonal
偶连物(Conjugation)icon
Unconjugated
免疫原(Immunogen)icon
Recombinant protein of human IL6RA(Met1-Pro365).
别名icon
Interleukin-6 receptor subunit alpha,IL-6 receptor subunit alpha,IL-6R subunit alpha,IL-6R-alpha,IL-6RA,IL-6R 1,Membrane glycoprotein 80,gp80,CD126,IL6R
Uniprot IDicon
P08887
状态(Form)icon
Liquid
储存溶液(Buffer)icon
PBS,pH7.4,containing 0.05% proclin300,50% glycerol.
存放条件(Storage)icon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4°C for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.
浓度(Concentration)icon
0.73mg/ml
亚型(Isotype)icon
IgG
分子量(MW)icon
52kDa
纯化方式(Purity)icon
Antigen affinity purification
WB,ICC,IHC
    PubMed:28265003;PMID: 2529343 ;PMID: 10066782
    Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R, the complex of IL-6 and IL-6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL-6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL-6R has been found in human serum and urine (PMID: 2529343,1545125).

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