Recombinant Human IL3RA protein ,C- His Tag

Recombinant Human IL3RA protein ,C- His Tag

>90% as determined by SDS-PAGE

Please contact with the lab for this information.

A DNA sequence encoding the human IL3RA(Met1-Arg305) was fused with the C-terminal His Tag

P26951

Mammalian cells

Homo sapiens (Human)

33.55kDa

Supplied as solution form in PBS or lyophilized from PBS .

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha

Rascu, Otelea, Mambet, Handra, Neagu, Rascu, Giurcaneanu, Diaconu (2020) Modified plasma cytokine profile in occupational dermatitis Endocrine, metabolic & immune disorders drug targets ()

For research use only .

Despite significant progress in the diagnosis of contact dermatitis, the identification of specific tests or biomarkers remains an unsolved issue, particularly when needed for the confirmation of the occupational origin of the disease. To characterize the plasma proteome profile in occupational dermatitis in workers from paint industry. The study has a case-control design, comparing exposed workers with and without occupational contact dermatitis, matched for age, gender, occupational history and comorbidities. An immunological assay (Human XL Cytokine Array Kit - ARY022B, R&D Systems) was used to measure the plasma levels of 105 cytokines and chemokines in a pooled sample of the cases and a pooled sample of the controls. A 1.5-fold increase was noticed for interleukin 3, interleukin 10 and leptin in cases, as compared to controls. Fibroblast growth factor-7 and growth/differentiation factor-15 showed a 1.4- fold increase, while interleukin 19, interleukin 31 and macrophage inflammatory protein 3 α had only a 1.3-fold increase. Leukemia inhibitory factor was the only plasma cytokine that showed a 1.3-fold decrease. All other cytokines had a variation of less than 1.2-fold between cases and controls. The recognition of the molecular signatures is very important for an accurate and indisputable diagnosis of occupational contact dermatitis. In workers from paint industry, plasma levels of interleukins 3, 10, 13 and 19, fibroblast growth factor-7, and growth/differentiation factor-15 together with leukemia inducible factor may differentiate subjects with contact dermatitis from those without skin lesions.

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