普健生物(武汉)科技有限公司(AtaGenix)

Anti TMPRSS2 polyclonal antibody

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产品概述(Summary)icon
产品名称(Product name)
Anti TMPRSS2 polyclonal antibody
描述(description)
Produced in rabbits immunized with purified,Recombinant Human TMPRSS2 protein
Accession #
O15393
别名(Alternative names)
PP9284, PRSS10, Serine protease 10, TMPRSS2
稳定性&储存(Stability &Storage)
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -99 °C for twelve months from the date of receipt.
特异性(Spcificty)
Recognizes Human TMPRSS2 protein
亚型(Isotype)
IgG
宿主(Host)
Rabbit
克隆性(Clonality)
Polyclonal
偶连物(Conjugation)
Unconjugated
种属反应性(Species reactivity)
Human,other species was not test
应用实验(Tested applications)
WB,IHC
免疫原(Immunogen)
Recombinant Human TMPRSS2 protein
背景(Background)icon
TMPRSS2, also named as PRSS10, is a type II transmembrane serine protease which is highly expressed by the epithelium of the human prostate gland. TMPRSS2 may contribute to prostate tumour metastasis via the activation of PAR-2. TMPRSS2 is a Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. TMPRSS2 as a host cell factor that is critical for spread of several clinically relevant viruses, including influenza A viruses and coronaviruses.SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. The initial spike protein priming by TMPRSS2 is essential for entry and viral spread of SARS-CoV-2 through interaction with the ACE2 receptor.Camostat mesylate, an inhibitor of TMPRSS2, can block SARS-CoV-2 infection of lung cells.The MW of TMPRSS2 is about 65-70 kDa. It can be cleaved in to some chains with MW 54 kDa, 31 kDa and 26 kDa
产品性能( Product performance)icon
状态(Form)
Liquid
储存溶液(Buffer)
PBS,pH7.4,containing 0.05% proclin300,50% glycerol.
浓度(Concentration)
0.5mg/ml
分子量(MW)
54kDa
应用(Application)icon
应用实验及稀释比例(Dilution Range)
WB:1:2000-1:8000,IHC:1:200-1:400
产品实验图片(Tested Picture)icon
    Noteicon
    For research use only .
    PMID: 23468491, 30626688;PMID: 32142651, 30626688 ;PMID: 32142651;PMID: 25734995, 20382709, 26018085

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