产品名称(Product name)
Anti 2019-nCoV Spike glycoprotein monoclonal antibody
描述(description)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant SARS-CoV-2(2019-nCoV) Spike glycoprotein
Accession #
P0DTC2
别名(Alternative names)
Anti S glycoprotein antibody ,Anti Spike protein S2 antibody,Anti Peplomer protein antibody,Anti E2 antibody
稳定性&储存(Stability &Storage)
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -99 °C for twelve months from the date of receipt.
特异性(Spcificty)
Recognizes SARS-CoV-2 Spike glycoprotein
亚型(Isotype)
IgG2b
宿主(Host)
Mouse
克隆性(Clonality)
Monoclonal
克隆号(Clone No.)
16-F-28
偶连物(Conjugation)
Unconjugated
种属反应性(Species reactivity)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
应用实验(Tested applications)
Elisa,WB
免疫原(Immunogen)
Recombinant SARS-CoV-2 Spike protein fragment 2[Y1047-Q1210]
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
状态(Form)
Liquid
储存溶液(Buffer)
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
浓度(Concentration)
0.6mg/ml
分子量(MW)
142kDa
应用实验及稀释比例(Dilution Range)
Elisa:1:4000~1:8000,WB:1:1000~5000