普健生物(武汉)科技有限公司(AtaGenix)

Anti 2019-nCoV S2 Protein polyclonal antibody

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ATP243
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  • 产品信息(Product Details)
  • 参考文献
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  • 说明书
产品概述(Summary)icon
产品名称(Product name)
Anti 2019-nCoV S2 Protein polyclonal antibody
货号(Catalog#)
ATP243
描述(description)
Produced in rabbits immunized with purified,Recombinant SARS-CoV-2 S2 Protein
Accession #
P0DTC2
别名(Alternative names)
Spike glycoprotein,E2,Peplomer protein,Spike protein S2,S
稳定性&储存(Stability &Storage)
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -88 °C for twelve months from the date of receipt.
特异性(Spcificty)
Recognizes SARS-CoV-2 S2 Protein
亚型(Isotype)
IgG
宿主(Host)
Rabbit
克隆性(Clonality)
Polyclonal
偶连物(Conjugation)
Unconjugate
种属反应性(Species reactivity)
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
应用实验(Tested applications)
Elisa
免疫原(Immunogen)
Recombinant SARS-CoV-2 S2 Protein(Ser686-Pro1213)
背景(Background)icon
Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
产品性能( Product performance)icon
状态(Form)
Liquid
储存溶液(Buffer)
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
浓度(Concentration)
0.61mg/ml
分子量(MW)
141kDa
应用(Application)icon
应用实验及稀释比例(Dilution Range)
Elisa:1:4000~1:8000
Noteicon
For research use only .
Huang, Y., Yang, C., Xu, X. et al. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin 41, 1141–1149 (2020). https://doi.org/10.1038/s41401-020-0485-4;Ou, X., Liu, Y., Lei, X. et al. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun 11, 1620 (2020). https://doi.org/10.1038/s41467-020-15562-9

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