普健生物(武汉)科技有限公司(AtaGenix)

Daclizumab ( 达克珠单抗 )

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ATAD00005
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货号(Catalog No.)icon
ATAD00005
通用名INNicon
Daclizumab
纯度(Purity)icon
>95%
电泳图(SDS-PAGE image)icon
    浓度( Concentration)icon
    1.73 mg/ml
    Formulationicon
    PBS buffer PH7.4
    Sourceicon
    CHO cells
    内毒素(Endotoxin level)icon
    Please contact with the lab for this information.
    生物活性icon
    产品描述(Description)
    Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Daclizumab is a composite of human (90%) and murine (10%) antibody sequences.The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody.The murine sequences were derived from the complementarity-determining regions of a murine anti-Tac antibody.On 22 April 2008,Roche Registration Limited chose to voluntarily withdraw the marketing authorization for their product Zenapax (daclizumab), as indicated for the prophylaxis of acute organ rejection in de novo allogeneic renal transplantation and used concomitantly with an immunosuppressive regimen like cyclosporine and corticosteroids in patients who are not hight immunized,for commercial reasons and confirmed that this decision was not related to any safety concerns associated with the use of Zenapax (daclizumab) 2.Regardless of the withdrawal of Zenapax, Biogen and Abbvie's Zinbryta (daclizumab),as indicated for the treatment of adult patients with relapsing forms of multiple sclerosis,was approved for use by the FDA in 2016.
    别名(Alternative names)
    BIIB019,DAC HYP
    靶点;物种(Specificity target name;species)
    IL2RA[Homo sapiens]
    种类(Species)
    Humanized
    受体鉴定(Receptor identification)
    IgG1-kappa
    活性验证(图片、数据)(Bioactivity)icon
      化学信息icon
      分子量(MV)
      142612.1 Da
      CAS
      152923-56-3
      存储条件(Storage)
      Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
      Store at +4°C short term (1-2 weeks).
      Store at -20 °C 12 months.
      Store at -80°C long term.
      Noteicon
      For research use only .

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