普健生物（武汉）科技有限公司（AtaGenix）
Ruplizumab ( 卢利珠单抗 )
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- 产品信息
- 如何订购
- 说明书
货号（Catalog No.）icon
ATAD00002
通用名INNicon
Ruplizumab
纯度(Purity)icon
>95%
电泳图（SDS-PAGE image）icon
浓度( Concentration)icon
1mg/ml
Formulationicon
PBS buffer PH7.5
Sourceicon
CHO cells
内毒素(Endotoxin level)icon
Please contact with the lab for this information.
生物活性icon
产品描述(Description)
Ruplizumab is a humanized monoclonal antibody used as an immunosuppressive drug and is a component of Antova.Ruplizumab is an anti-CD40L monoclonal antibody.The binding of CD40 to its ligand,CD40L is a critical element in T cell activation.In systemic lupus erythematosus,CD40L is over-expressed on T cells, B cells and monocytes.
别名(Alternative names)
BG-9588,hu5c8
靶点;物种(Specificity target name;species)
CD40LG[Homo sapiens]
靶点背景信息(Target information)
Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
种类(Species)
Humanized
受体鉴定(Receptor identification)
IgG1-kappa
化学信息icon
分子量(MV)
145448.00 Da
CAS
220651-94-5
存储条件(Storage)
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Noteicon
For research use only .
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